Chemical Name: 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide
Biological ActivityCP 471474 is a broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Matrix metalloproteinease inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice.
Rohde et al.
Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction.
Lindsey et al.
Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction.
Fang et al.
Citations for CP 471474
The citations listed below are publications that use Tocris products. Selected citations for CP 471474 include:
3 Citations: Showing 1 - 3
Cleavage/Alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract.
Authors: Zariffard Et al.
PLoS One 2015;10:e0116911
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
Authors: Brafman Et al.
PLoS One 2013;20:369
MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation.
Authors: Meierjohann Et al.
Mol Cancer 2010;9:201
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