Cultrex Basement Membrane Extract, 5X Solution

Discontinued Product

3455-096-02 has been discontinued.
View all Basement Membrane Extracts products.
Product Details
Citations (4)

Cultrex Basement Membrane Extract, 5X Solution Summary

Cultrex 5X Basement Membrane Extract (BME) Solution is designed for use in Cultrex BME Cell Invasion Assays.

Why Use Cultrex BME, 5X Solution?

Cultrex Basement Membrane Extract (BME) is a soluble form of basement membrane purified from Engelbreth-Holm-Swarm (EHS) tumor. This extract provides a natural extracellular matrix hydrogel that polymerizes at 37°C to form a reconstituted basement membrane. Basement membranes are continuous sheets of specialized extracellular matrix that form an interface between endothelial, epithelial, muscle, or neuronal cells and their adjacent stroma and that play an essential role in tissue organization by influencing cell adhesion, migration, proliferation, and differentiation. The major components of BME include laminin, collagen IV, entactin, and heparin sulfate proteoglycans.


Murine Engelbreth-Holm-Swarm (EHS) tumor
Endotoxin Level
≤ 8 EU/mL by Limulus Amoebocyte Lysate (LAL) assay
Sterility Testing
Tested following USP <71> sterility guidelines.
Testing Cell Culture
Performance tested in Cultrex BME Cell Invasion Assay.
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.


For research use only. Not for diagnostic use.

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Citations for Cultrex Basement Membrane Extract, 5X Solution

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. Porcine pancreatic ductal epithelial cells transformed with KRASG12D and SV40T are tumorigenic
    Authors: KL Bailey, SB Cartwright, NS Patel, N Remmers, AJ Lazenby, MA Hollingswo, MA Carlson
    Scientific Reports, 2021;11(1):13436.  2021
  2. Fra-2/AP-1 regulates melanoma cell metastasis by downregulating Fam212b
    Authors: GL Chen, R Li, XX Chen, J Wang, S Cao, R Song, MC Zhao, LM Li, N Hannemmann, G Schett, C Qian, A Bozec
    Cell Death Differ, 2020;0(0):.  2020
  3. N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway
    Authors: Y Yin, L Xu, Y Chang, T Zeng, X Chen, A Wang, J Groth, WC Foo, C Liang, H Hu, J Huang
    Mol. Cancer, 2019;18(1):11.  2019
  4. Ah receptor antagonism represses head and neck tumor cell aggressive phenotype.
    Authors: DiNatale B, Smith K, John K, Krishnegowda G, Amin S, Perdew G
    Mol Cancer Res, 0;10(10):1369-79.  0


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