D-64131

Tocris Bioscience | Catalog # 1643

Tubulin polymerization inhibitor. Antitumor in vivo
Tocris Bioscience
Discontinued Product
1643 has been discontinued. View all Microtubule Binding Compounds products.

Key Product Details

Description

Tubulin polymerization inhibitor. Antitumor in vivo
View all Microtubule Binding Compounds »

Product Description

D-64131 is a novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo.

Product Specifications for D-64131

Molecular Weight

251.28

Formula

C16H13NO2

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

(5-Methoxy-1H-indol-2-yl)phenylmethanone

CAS Number

74588-78-6

PubChem ID

3921152

InChI Key

ICMIJSRDISNKOC-UHFFFAOYSA-N

SMILES

COC1=CC=C2NC(=CC2=C1)C(=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.13 100
Ethanol 5.03 20

Preparing Stock Solutions for D-64131

The following data is based on the product molecular weight 251.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.98 mL 19.90 mL 39.80 mL
5 mM 0.80 mL 3.98 mL 7.96 mL
10 mM 0.40 mL 1.99 mL 3.98 mL
50 mM 0.08 mL 0.40 mL 0.80 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for D-64131

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for D-64131

For research use only

Related Research Areas

Microtubules

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  • The antitumoral efficacy of D-64131 in comparison to paclitaxel and vincristine
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/23/2019
    The antitumoral efficacy of D-64131 in comparison to paclitaxel and vincristine was evaluated in resistance mediated by the MRP and in human tumor cells with resistance to cisplatin, the topoisomerase I inhibitor SN-38 (7-ethyl-10-hydroxycamptothecin) and the thymidylate synthase inhibitors 5-fluorouracil and raltitexed.
    D-64131 1643

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