Catalog Number: 1643
Chemical Name: (5-Methoxy-1H-indol-2-yl)phenylmethanone
Biological Activity
Novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors.
    Beckers et al.
    Cancer Res., 2002;62:3113
  2. Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents.
    Mahboobi et al.
    J.Med.Chem., 2001;44:4535

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