Chemical Name: (5-Methoxy-1H-indol-2-yl)phenylmethanone
Biological ActivityD-64131 is a novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors.
Beckers et al.
Cancer Res., 2002;62:3113
Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents.
Mahboobi et al.
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The antitumoral efficacy of D-64131 in comparison to paclitaxel and vincristine was evaluated in resistance mediated by the MRP and in human tumor cells with resistance to cisplatin, the topoisomerase I inhibitor SN-38 (7-ethyl-10-hydroxycamptothecin) and the thymidylate synthase inhibitors 5-fluorouracil and raltitexed.