Phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3
). Potent inhibitor of Ins (1,4,5)P3
~150 nM); facilitates Ca2+
influx by sensitizing Ins (1,4,5)P3
-mediated activation of ICRAC
. At higher concentrations, acts as an inhibitor of Ins (1,4,5)P3
Soluble in water
Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Agonist-induced calcium signaling is impaired in fibroblasts overproducing inositol 1,3,4,5-tetrakisphosphate.
Balla et al.
Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling.
Cullen et al.
InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphatase.
Hermosura et al.