Catalog Number: 1420
Biological Activity
Phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Potent inhibitor of Ins (1,4,5)P3 5-phosphatase (IC50 ~150 nM); facilitates Ca2+ influx by sensitizing Ins (1,4,5)P3-mediated activation of ICRAC. At higher concentrations, acts as an inhibitor of Ins (1,4,5)P3�receptors.
Technical Data
  • M.Wt:
    804.73
  • Formula:
    C6H8O18P4.K8
  • Solubility:
    Soluble in water
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    145843-69-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Agonist-induced calcium signaling is impaired in fibroblasts overproducing inositol 1,3,4,5-tetrakisphosphate.
    Balla et al.
    J.Biol.Chem., 1991;266:24719
  2. Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling.
    Cullen et al.
    Biochim.Biophys.Acta, 1998;1436:35
  3. InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphatase.
    Hermosura et al.
    Nature, 2000;408:735

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