Potent thioredoxin reductase (TrxR) inhibitor (EC50
= 2.8 nM, IC50
= 0.03 and 0.1 μM in MCF-7 cells and HT-29 cells, respectively). Highly stable in vivo
; exhibits no significant ligand exchange with albumin. Inhibits tumor proliferation in vitro
and in vivo
by inducing cell death. Selectively kills cancer cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Synthesis and molecular recognition studies on small-molecule inhibitors for thioredoxin reductase.
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