Chemical Name: (Diphenyl-2-thienylphosphine-κP)[2-(4-methoxyphenyl)ethynyl]gold
Biological ActivityPotent thioredoxin reductase (TrxR) inhibitor (EC50 = 2.8 nM, IC50 = 0.03 and 0.1 μM in MCF-7 cells and HT-29 cells, respectively). Highly stable in vivo; exhibits no significant ligand exchange with albumin. Inhibits tumor proliferation in vitro and in vivo by inducing cell death. Selectively kills cancer cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and molecular recognition studies on small-molecule inhibitors for thioredoxin reductase.
Zhang et al.
pH-sensitive polymeric nanoparticles with gold(I) compound payloads synergistically induce cancer cell death through modulation of autophagy.
Lin et al.
Citation for D9
The citations listed below are publications that use Tocris products. Selected citations for D9 include:
1 Citation: Showing 1 - 1
Pyridine nucleotide regulation of hepatic endoplasmic reticulum calcium uptake.
Authors: Wang Et al.
Physiol Rep 2019;7:e14151
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