DC 271

Tocris Bioscience | Catalog # 6873

Fluorescent retinoic acid analog; solvochromatic probe
Tocris Bioscience
Discontinued Product
6873 has been discontinued. View all Fluorescent Receptor Probes products.

Key Product Details

Description

Fluorescent retinoic acid analog; solvochromatic probe
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Product Description

DC 271 is a fluorescent retinoic acid analog (retinoid all-trans-retinoic acid; ATRA) (Kd = 42 nM at cellular retinoid binding protein II (CRABPII)). Solvochromatic probe: fluorescent λex, λem, and quantum yield affected by solvent type. DC 271 can be used in retinoids assays. Activates same genes as endogenous retinoic acid in human keratinocyte cells (HaCaT) when incubated for 72 h at 1 μM. Also elicits cellular responses consistent with those of retinoic acid. Excitation λ = 351, 350, 382 and 378 nm in DMSO, EtOH, DCM and Toluene, respectively; emission λ = 442, 461, 572 and 447 nm in DMSO, EtOH, DCM and Toluene, respectively. Quantum yield = 19.3, 1.14, 71.45, 80.21 % in DMSO, EtOH, DCM and Toluene, respectively.

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Product Specifications for DC 271

Molecular Weight

347.46

Formula

C23H25NO2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[2-[1,2,3,4-Tetrahydro-4,4-dimethyl-1-(1-methylethyl)-6-quinolinyl]ethynyl]benzoic acid

CAS Number

198696-03-6

PubChem ID

22971725

InChI Key

OCMSZODRCJAGHL-UHFFFAOYSA-N

SMILES

CC(N1CCC(C)(C2=CC(C#CC3=CC=C(C(O)=O)C=C3)=CC=C12)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.37 50
Ethanol 3.47 10

Preparing Stock Solutions for DC 271

The following data is based on the product molecular weight 347.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.76 mL 28.78 mL 57.56 mL
2.5 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
25 mM 0.12 mL 0.58 mL 1.15 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for DC 271

Certificate of Analysis

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Product Specific Notices for DC 271

For research use only

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