DETA NONOate
Discontinued Product
6077 has been discontinued.
View all Nitric Oxide Donor/Precursor Compounds products.
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Description: Nitric oxide donor
Chemical Name: 2,2'-(2-Hydroxy-2-nitrosohydrazinylidene)bis-ethanamine
Biological Activity
Nitric oxide donor. Activates an inward current in cultured rat cerebellar granules cells. Increases cGMP production in cultured vascular smooth muscle cells. Reduces contractility of cardiac muscle preparations in vitro.Technical Data
M.Wt:
163.18
Formula:
C4H13N5O2
Solubility:
Soluble to 100 mM in water
Storage:
Store at -20°C
CAS No:
146724-94-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide.
Thompson et al.
Br.J.Pharmacol., 2009;158:1338 -
Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation.
Olson et al.
Hypertension, 1997;29:254 -
Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice.
Wegener et al.
Br.J.Pharmacol., 2002;136:415
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