Catalog Number: 2805
Alternate Names: Ro 5-2807
Chemical Name: 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one
Biological Activity
Ligand at the GABAA receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.
Technical Data
  • M.Wt:
    284.74
  • Formula:
    C16H13ClN2O
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    439-14-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacology of benzodiazepine receptors: an update.
    Sieghart et al.
    J.Psychiat.Neurosci., 1994;19:24
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Diazepam include:

2 Citations: Showing 1 - 2
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  1. Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
    Authors: Czysz Et al.
    PLoS One 2015;40:766
  2. In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383.
    Authors: Ufuk Et al.
    Pharm Res 2015;32:3937

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