Chemical Name: 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one
Biological ActivityLigand at the GABAA receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacology of benzodiazepine receptors: an update.
Sieghart et al.
Citations for Diazepam
The citations listed below are publications that use Tocris products. Selected citations for Diazepam include:
8 Citations: Showing 1 - 8
Structure of a human synaptic GABAA receptor.
Local GABAA receptor mediated suppression of DA release within the nucleus accumbens.
Authors: Brodnik Et al.
ACS Chem Neurosci 2018;17:1978
Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
Authors: Czysz Et al.
PLoS One 2015;40:766
In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383.
Authors: Ufuk Et al.
Pharm Res 2015;32:3937
Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT?A and 5-HT? Antagonists in Animal Models.
Authors: Pytka Et al.
PLoS One 2015;10:e0142499
Membrane potential measurements of isolated neurons using a voltage-sensitive dye.
Authors: Fairless Et al.
PLoS One 2013;8:e58260
A translational rodent assay of affective biases in depression and antidepressant therapy.
Authors: Stuart Et al.
A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure.
Authors: Huang Et al.
J Neurosci 2010;30:16636
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