DiMNF
Discontinued Product
Chemical Name: 2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
Purity: ≥99%
Biological Activity
DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Suppresses expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment; exhibits no effect on basal CD55 or CD46 expression.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Distinct roles for aryl hydrocarbon receptor nuclear translocator and Ah receptor in estrogen-mediated signaling in human cancer cell lines.
Labrecque et al.
PLoS ONE, 2012;7:e29545 -
Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure.
Narayanan et al.
J.Pharmacol.Exp.Ther., 2012;342:345 -
Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone.
Murray et al.
Mol.Pharmacol., 2011;79:508
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Used this compound to test published results, had great success. Dissolved easily in DMSO
