DMAB-anabaseine dihydrochloride
Discontinued Product
Chemical Name: 4-[(5,6-Dihydro[2,3'-bipyridin]-3(4H)-ylidene)methyl]-N,N-dimethylbenzenamine dihydrochloride
Purity: ≥98%
Biological Activity
Partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Displays specific cognition-enhancing effects; improves long-term memory in rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors.
Kem et al.
J.Pharmacol.Exp.Ther., 1997;283:979 -
Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21.
Arendash et al.
Brain Res., 1995;674:252 -
Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice.
Stevens et al.
Psychopharmacology, 1998;136:320
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