Partial agonist at α
7-containing neuronal nicotinic receptors and antagonist at α
2 and other nicotinic receptors. Displays specific cognition-enhancing effects; improves long-term memory in rats.
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Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors.
Kem et al.
Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21.
Arendash et al.
Brain Res., 1995;674:252
Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice.
Stevens et al.