Catalog Number: 2241
Chemical Name: 4-[(5,6-Dihydro[2,3'-bipyridin]-3(4H)-ylidene)methyl]-N,N-dimethylbenzenamine dihydrochloride
Biological Activity
Partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Displays specific cognition-enhancing effects; improves long-term memory in rats.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 25 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors.
    Kem et al.
    J.Pharmacol.Exp.Ther., 1997;283:979
  2. Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21.
    Arendash et al.
    Brain Res., 1995;674:252
  3. Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice.
    Stevens et al.
    Psychopharmacology, 1998;136:320
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