Catalog # Availability Size / Price Qty
Domperidone | CAS No. 57808-66-9 | Non-selective Dopamine Receptor Antagonists
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Description: Peripheral D2-like antagonist
Alternative Names: R 33812

Chemical Name: 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

Purity: ≥99%

Product Details
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Biological Activity

Domperidone is a peripheral dopamine D2-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).

Technical Data

Soluble to 5 mM in 1eq. HCl and to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The antiemetic effects of domperidone, a novel potent gastrokinetic.
    Neimegeers et al.
    Arch.Int.Pharmacodyn.Ther., 1980;244:130
  2. Domperidone. A review of its use in diabetic gastropathy.
    Prakash and Wagstaff
    Drugs, 1998;56:429
  3. DA D2, but not D4, receptor agonists are emetogenic in ferrets.
    Osinski et al.
    Pharmacol.Biochem.Behav., 2005;81:211

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