Chemical Name: 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
Biological ActivityDomperidone is a peripheral dopamine D2-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The antiemetic effects of domperidone, a novel potent gastrokinetic.
Neimegeers et al.
Domperidone. A review of its use in diabetic gastropathy.
Prakash and Wagstaff
DA D2, but not D4, receptor agonists are emetogenic in ferrets.
Osinski et al.
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