Catalog Number: 0841
Chemical Name: 1,3-Di-(2-tolyl)guanidine
Biological Activity
Displays high and roughly equal affinity for both σ1 and σ2 receptors.
Technical Data
  • M.Wt:
    239.32
  • Formula:
    C15H17N3
  • Solubility:
    Soluble to 25 mM in ethanol and to 25 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    97-39-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and binding characteristics of potential SPECT imaging agents for σ1 and σ2 binding sites.
    He et al.
    J.Med.Chem., 1993;36:566
  2. A proposal for the classification of sigma binding sites.
    Quirion et al.
    TiPS, 1992;13:85
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DTG include:

2 Citations: Showing 1 - 2
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  1. σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons.
    Authors: Pan Et al.
    Neuroscience 2014;350:290
  2. Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation.
    Authors: Hall Et al.
    PLoS One 2009;164:470

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