Catalog Number: 0869
Chemical Name: 2-Phenyl-1,3-propanedioldicarbamate
Biological Activity
Anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site.
Technical Data
  • M.Wt:
    238.24
  • Formula:
    C11H14N2O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    25451-15-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
    De Sarro et al.
    Eur.J.Pharmacol., 1994;262:11
  2. Selective antagonism of the anticonvulsant effects of felbamate by glycine.
    Coffin et al.
    Eur.J.Pharmacol., 1994;256:R9
  3. Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings.
    Upton
    TiPS, 1994;15:456
  4. Felbamate antagonises isoniazid- and FG7142-induced reduction of GABAA receptor function in the mouse brain.
    Serra et al.
    Eur.J.Pharmacol., 1994;265:185

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