Felbamate
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Description: NMDA antagonist; acts at glycine site
Chemical Name: 2-Phenyl-1,3-propanedioldicarbamate
Purity: ≥99%
Biological Activity
Felbamate is an anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site.Technical Data
M.Wt:
238.24
Formula:
C11H14N2O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
25451-15-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Felbamate antagonises isoniazid- and FG7142-induced reduction of GABAA receptor function in the mouse brain.
Serra et al.
Eur.J.Pharmacol., 1994;265:185 -
Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings.
Upton
TiPS, 1994;15:456 -
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felb. in DBA/2 mice.
De Sarro et al.
Eur.J.Pharmacol., 1994;262:11 -
Selective antagonism of the anticonvulsant effects of felb. by glycine.
Coffin et al.
Eur.J.Pharmacol., 1994;256:R9
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