Chemical Name: Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide copper complex
Biological ActivityAkt/PKB inhibitor (IC50 = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells.
Barve et al.
Citation for FPA 124
The citations listed below are publications that use Tocris products. Selected citations for FPA 124 include:
1 Citation: Showing 1 - 1
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.
Authors: Liddell Et al.
J Neuroinflammation 2016;13:49
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VersaClone cDNA Plasmids
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