Akt/PKB inhibitor (IC50
= 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro
and decreases NF-κ
B activity and tumor load in vivo
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Sold under license from Wayne State University
Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells.
Barve et al.