FPA 124

Key Product Details

Product Description

FPA 124 is an Akt/PKB inhibitor (IC₅₀ = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.

Product Specifications for FPA 124

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FPA 124

The following data is based on the product molecular weight 381.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.20 mL	130.98 mL	261.97 mL
0.5 mM	5.24 mL	26.20 mL	52.39 mL
1 mM	2.62 mL	13.10 mL	26.20 mL
5 mM	0.52 mL	2.62 mL	5.24 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Barve Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J.Med.Chem. 2006 PMID: 16789737

Product Documents for FPA 124