A highly potent and selective ETA
endothelin receptor antagonist (Ki
values are 1 nM and 7.3 μ
M at ETA
subtypes respectively). Active in vivo
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All Tocris products are intended for laboratory research use only.
Subtype selectivity of a novel endothelin antagonist, FR139317, for the two endothelin receptors in transfected Chinese hamster ovary cells.
Aramori et al.
Role of endothelin ETA- and ETB-receptors in haemodynamic compensation following haemorrhage in anaesthetized rats.
Palacios et al.
Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.
Rubanyi and Polokoff
Pharmacological profile of FR139317, a novel, potent endothelin ETA receptor antagonist.
Sogabe et al.