Chemical Name: 3-Hydroxy-5-[[(2-Naphthalenylamino)carbonyl]amino]benzoic acid
Biological ActivityFrizzled 4 allosteric agonist (pEC50 = 6.4). Potentiates the β-catenin pathway in the absence of any WNT ligand, by biasing FZD4 signaling toward the FZD4/PI3K axis. Preserves stemness and promotes proliferation of undifferentiated cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist.
Riccio et al.
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