Chemical Name: Tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one-1,1-dioxide
Biological ActivityG5 is an ubiquitin isopeptidase inhibitor; activates caspases and apoptosis in an apoptosome-independent pathway.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.
Aleo et al.
Cancer Res., 2006;66:9235
NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway.
Hafner-Bratkovic et al.
Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system.
Foti et al.
Mol.Cancer Ther., 2009;8:3140
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