Chemical Name: Tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one-1,1-dioxide
Biological ActivityUbiquitin isopeptidase inhibitor; activates caspases and apoptosis in an apoptosome-independent pathway.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.
Aleo et al.
Cancer Res., 2006;66:9235
NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway.
Hafner-Bratkovic et al.
Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system.
Foti et al.
Mol.Cancer Ther., 2009;8:3140
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