Gabapentin
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Description: Increases brain GABA; anticonvulsant
Chemical Name: 1-(Aminomethyl)cyclohexaneacetic acid
Purity: ≥99%
Biological Activity
Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca2+ channels. Prevents neuronal death and is antinociceptive and anxiolytic.Technical Data
M.Wt:
171.24
Formula:
C9H17NO2
Solubility:
Soluble to 100 mM in water with gentle warming
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
60142-96-3
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
-
Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings.
Upton
TiPS, 1994;15:456 -
Inhibition of Ca2+ influx by gabap. and subsequent reduction of neurotransmitter release from rat neocortical slices.
Fink et al.
Br.J.Pharmacol., 2000;130:900 -
A summary of mechanistic hypotheses of gabap. pharmacology.
Taylor et al.
Epilepsy Res., 1998;29:233 -
A microdialysis study on the mechanism of action of gabap.
Timmerman et al.
Eur.J.Pharmacol., 2000;398:53
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