Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca2+
channels. Prevents neuronal death and is antinociceptive and anxiolytic.
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All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
Inhibition of Ca2+ influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices.
Fink et al.
Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings.
A microdialysis study on the mechanism of action of gabapentin.
Timmerman et al.
A summary of mechanistic hypotheses of gabapentin pharmacology.
Taylor et al.
Epilepsy Res., 1998;29:233
The citations listed below are publications that use Tocris products. Selected citations for Gabapentin include:
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