Catalog Number: 0806
Chemical Name: 1-(Aminomethyl)cyclohexaneacetic acid
Biological Activity
Anticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca2+ channels. Prevents neuronal death and is antinociceptive and anxiolytic.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water with gentle warming
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Inhibition of Ca2+ influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices.
    Fink et al.
    Br.J.Pharmacol., 2000;130:900
  2. Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings.
    TiPS, 1994;15:456
  3. A microdialysis study on the mechanism of action of gabapentin.
    Timmerman et al.
    Eur.J.Pharmacol., 2000;398:53
  4. A summary of mechanistic hypotheses of gabapentin pharmacology.
    Taylor et al.
    Epilepsy Res., 1998;29:233

The citations listed below are publications that use Tocris products. Selected citations for Gabapentin include:

Showing Results 1 - 1 of 1

  1. Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization.
    Authors: Sant'Anna Et al.
    J Neurosci
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