Chemical Name: 1-(Aminomethyl)cyclohexaneacetic acid
Biological ActivityAnticonvulsant with several possible mechanisms of action. Increases GABA in the brain and binds to a novel site associated with voltage-sensitive Ca2+ channels. Prevents neuronal death and is antinociceptive and anxiolytic.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings.
Inhibition of Ca2+ influx by gabap. and subsequent reduction of neurotransmitter release from rat neocortical slices.
Fink et al.
A summary of mechanistic hypotheses of gabap. pharmacology.
Taylor et al.
Epilepsy Res., 1998;29:233
A microdialysis study on the mechanism of action of gabap.
Timmerman et al.
Citation for Gabapentin
The citations listed below are publications that use Tocris products. Selected citations for Gabapentin include:
1 Citation: Showing 1 - 1
Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization.
Authors: Sant'Anna Et al.
J Neurosci 2016;6:26955
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