Calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.
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Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels.
Nishitani et al.
PLoS One., 2011;6:e26181
The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells.
Del Favero et al.
The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration.
Nagata et al.
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Lee et al.
The citations listed below are publications that use Tocris products. Selected citations for Gadolinium chloride include:
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