Biological ActivityGadolinium chloride is a calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.
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Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels.
Nishitani et al.
PLoS One., 2011;6:e26181
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Lee et al.
The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells.
Del Favero et al.
The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration.
Nagata et al.
Citations for Gadolinium chloride
The citations listed below are publications that use Tocris products. Selected citations for Gadolinium chloride include:
3 Citations: Showing 1 - 3
Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation.
Authors: Dela Paz
Biochem Biophys Res Commun 2018;497(1):220
Quantum dots modulate intracellular Ca2+level in lung epithelial cells.
Authors: Yin Et al.
Int J Nanomedicine 2017;12:2781
Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons.
Authors: Szteyn Et al.
J Immunol 2015;7
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Reviews for Gadolinium chloride
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we used it to inhibit store-operated calcium channels, more specifically Calcium release activated channels (CRAC). Worked as expected although some changes to the media was needed.