STAT3 inhibitor. Irreversibly binds STAT3 and inhibits binding to DNA. Inhibits IL-6-dependent JAK/STAT signaling. Induces cell-cycle arrest in G2
/M phase and apoptosis in androgen-insensitive prostate cancer cells via activation of ATM/ATR pathway. Also destabilizes microtubules and inhibits cell migration. Exhibits anticancer effects in a mouse tumor xenograft model.
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Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells.
Don-Doncow et al.
Inhibition of interleukin-6 signaling by galiellalactone.
Weilder et al.
FEBS Lett., 2000;484:1
Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells.
Garcia et al.