Galiellalactone

Key Product Details

Product Description

Galiellalactone is a STAT3 inhibitor. Irreversibly binds STAT3 and inhibits binding to DNA. Inhibits IL-6-dependent JAK/STAT signaling. Induces cell-cycle arrest in G₂/M phase and apoptosis in androgen-insensitive prostate cancer cells via activation of ATM/ATR pathway. Also destabilizes microtubules and inhibits cell migration. Exhibits anticancer effects in a mouse tumor xenograft model.

Product Specifications for Galiellalactone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Galiellalactone

The following data is based on the product molecular weight 194.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	102.97 mL	514.85 mL	1,029.71 mL
0.25 mM	20.59 mL	102.97 mL	205.94 mL
0.5 mM	10.30 mL	51.49 mL	102.97 mL
2.5 mM	2.06 mL	10.30 mL	20.59 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Weilder Inhibition of interleukin-6 signaling by galiellalactone. FEBS Lett. 2000 PMID: 11056211
• Garcia Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells. Oncotarget 2016 PMID: 26683224
• Don-Doncow Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. J.Biol.Chem. 2014 PMID: 24755219

Product Documents for Galiellalactone