GANT 58

  ( 1 citations )    
Product Datasheet
Catalog Number:3889
Chemical Name:2,3,4,5-Tetra(4-pyridyl)thiophene
Product Details
Citations (1)
Reviews
Biological Activity
GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.
Technical Data
  • M.Wt:
    392.48
  • Formula:
    C24H16N4S
  • Solubility:
    Soluble to 25 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    64048-12-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for GANT 58 include:

1 Citations: Showing 1 - 1

  1. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.
    Authors: Oladapo
    Cancer Lett  2017;411:136

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