Biological Activity GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.
Soluble to 25 mM in DMSO and to 25 mM in ethanol
Store at +4°C
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All Tocris products are intended for laboratory research use only.
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