GLI antagonist that inhibits GLI1-induced transcription (IC50
= 5 μ
M). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo
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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.
Lauth et al.
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.
Beauchamp et al.
GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors.
Joo et al.
PLoS ONE, 2009;4:7608