Chemical Name: 2,3,4,5-Tetra(4-pyridyl)thiophene
Biological ActivityGANT 58 is a GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.
Lauth et al.
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.
Beauchamp et al.
GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors.
Joo et al.
PLoS ONE, 2009;4:7608
Citation for GANT 58
The citations listed below are publications that use Tocris products. Selected citations for GANT 58 include:
1 Citation: Showing 1 - 1
Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.
Cancer Lett 2017;411:136
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