Catalog Number: 3889
Chemical Name: 2,3,4,5-Tetra(4-pyridyl)thiophene
Biological Activity
GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO and to 25 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.
    Lauth et al.
    Proc.Natl.Acad.Sci., 2007;104:8455
  2. GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.
    Beauchamp et al.
    J.Biol.Chem., 2009;284:9074
  3. GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors.
    Joo et al.
    PLoS ONE, 2009;4:7608
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