Biological ActivityGap 26 is a peptide, corresponding to residues 63 - 75 of connexin 43, which is a gap junction blocker. Attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC50 = 28.4 μM). Also inhibits IP3-induced ATP release, without inhibiting gap junctional coupling in endothelial cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26.
Braet et al.
Cell Calcium, 2003;33:37
Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries.
Chaytor et al.
Citations for Gap 26
The citations listed below are publications that use Tocris products. Selected citations for Gap 26 include:
4 Citations: Showing 1 - 4
Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis.
Authors: Almad Et al.
Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells.
Authors: Thuringer Et al.
BMC Vet Res 2015;6:10267
Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells.
Authors: Jones Et al.
Sci Rep 2015;5:11694
Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo.
Authors: Sakatani Et al.
J Neurosci 2008;28:10928
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