Peptide, corresponding to residues 63 - 75 of connexin 43, which is a gap junction blocker. Attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC50
= 28.4 mM). Also inhibits IP3
-induced ATP release, without inhibiting gap junctional coupling in endothelial cells.
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Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26.
Braet et al.
Cell Calcium, 2003;33:37
Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries.
Chaytor et al.
The citations listed below are publications that use Tocris products. Selected citations for Gap 26 include:
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