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Gap 26

1950 4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1950/1
Gap 26
1 Image
Description: Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release
Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Gap 26 is a peptide, corresponding to residues 63 - 75 of connexin 43, which is a gap junction blocker. Attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC50 = 28.4 μM). Also inhibits IP3-induced ATP release, without inhibiting gap junctional coupling in endothelial cells.

Technical Data

M.Wt:
1550.79
Formula:
C70H107N19O19S
Sequence:
VCYDKSFPISHVR
Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
197250-15-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Gap 26

The citations listed below are publications that use Tocris products. Selected citations for Gap 26 include:

4 Citations: Showing 1 - 4

  1. Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis.
    Authors: Almad Et al.
    Glia  2016;64:1154
  2. Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells.
    Authors: Thuringer Et al.
    BMC Vet Res  2015;6:10267
  3. Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells.
    Authors: Jones Et al.
    Sci Rep  2015;5:11694
  4. Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo.
    Authors: Sakatani Et al.
    J Neurosci  2008;28:10928

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