GaTx2

Catalog # Availability Size / Price Qty
4911/100U
Cat.No. 4911 - GaTx2 | Val-Ser-Cys-Glu-Asp-Cys-Pro-Asp-His-Cys-Ser-Thr-Glu-Lys-Ala-Arg-Ala-Lys-Cys-Asp-Asn-Asp-Lys-Cys-Val-Cys-Glu-Pro-Ile | CAS No. 194665-85-5
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Description: High affinity, selective ClC-2 blocker; inhibits slow-gating
Alternative Names: Leiuropeptide II
Product Details
Reviews

Biological Activity

Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.

Technical Data

M.Wt:
3192.54
Formula:
C125H199N39O47S6
Sequence:
VSCEDCPDHCSTQKARAKCDNDKCVCEPI

(Modifications: Disulfide bridge: 3-19, 6-24, 10-26)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
194665-85-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia.
    Schiffhauer et al.
    Am.J.Physiol.Lung Cell Mol.Physiol., 2013;304:L324
  2. Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels.
    Thompson et al.
    J.Biol.Chem., 2009;284:26051

Product Datasheets

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