GaTx2

Tocris Bioscience | Catalog # 4911

High affinity, selective ClC-2 blocker; inhibits slow-gating
Tocris Bioscience
Discontinued Product
4911 has been discontinued. View all Other Chloride Channel Blockers products.

Key Product Details

Description

High affinity, selective ClC-2 blocker; inhibits slow-gating

Alternative Names

Leiuropeptide II
View all Other Chloride Channel Blockers »

Product Description

GaTx2 is a very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.

Product Specifications for GaTx2

Molecular Weight

3192.54

Formula

C125H199N39O47S6

Storage

Store at -20°C

CAS Number

194665-85-5

PubChem ID

90488986

InChI Key

NDCNPIYRYDSDEM-TZZHORBYSA-N

SMILES

[H]N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC2=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 58 publications citing the usage of this product.

Product Documents for GaTx2

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GaTx2

For research use only

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