Catalog # Availability Size / Price Qty
Other Chloride Channel Blockers Peptide
1 Image
Description: High affinity, selective ClC-2 blocker; inhibits slow-gating
Alternative Names: Leiuropeptide II
Product Details
Citations (1)

Biological Activity

Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.

Technical Data


(Modifications: Disulfide bridge: 3-19, 6-24, 10-26)

Soluble to 1 mg/ml in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels.
    Thompson et al.
    J.Biol.Chem., 2009;284:26051
  2. Dual activation of CFTR and CLCN2 by lubipro. in murine nasal epithelia.
    Schiffhauer et al.
    Am.J.Physiol.Lung Cell Mol.Physiol., 2013;304:L324

Product Datasheets

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Citation for GaTx2

The citations listed below are publications that use Tocris products. Selected citations for GaTx2 include:

1 Citation: Showing 1 - 1


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