Very high affinity ClC-2 blocker (apparent KD
~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC
, CaCC and KV
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All Tocris products are intended for laboratory research use only.
Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia.
Schiffhauer et al.
Am.J.Physiol.Lung Cell Mol.Physiol., 2013;304:L324
Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels.
Thompson et al.