Biological ActivityGaTx2 is a very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.
(Modifications: Disulfide bridge: 3-19, 6-24, 10-26)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels.
Thompson et al.
Dual activation of CFTR and CLCN2 by lubipro. in murine nasal epithelia.
Schiffhauer et al.
Am.J.Physiol.Lung Cell Mol.Physiol., 2013;304:L324
Citation for GaTx2
The citations listed below are publications that use Tocris products. Selected citations for GaTx2 include:
1 Citation: Showing 1 - 1
Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin.
Authors: Nighot Et al.
Exp Cell Res 2017;352:113
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