Biological ActivityVery high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.
(Modifications: Disulfide bridge: 3-19, 6-24, 10-26)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia.
Schiffhauer et al.
Am.J.Physiol.Lung Cell Mol.Physiol., 2013;304:L324
Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels.
Thompson et al.
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