Glimepiride

Catalog # Availability Size / Price Qty
2396/10
2396/50
Glimepiride | CAS No. 93479-97-1 | Inward Rectifier Potassium Channel Blockers
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Description: Kir6 (KATP) channel blocker
Alternative Names: Amaryl, Glimperide

Chemical Name: 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide

Purity: ≥98%

Product Details
Reviews (1)

Biological Activity

Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

Technical Data

M.Wt:
490.62
Formula:
C24H34N4O5S
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
93479-97-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Glimepiride was used to evaluate the role of BK channel modulation on insulin secretion
By Anonymous on 11/28/2018
Species: Human

In pancreatic beta cells,ATP dependent potassium channels regulate glucose-dependent insulin secretion and serve as the target for sulfonylurea drugs used to treat type 2 diabetes.To understand the role of BK channels on insulin secretion,Glimepiride was used.


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