Catalog Number: 2396
Alternate Names: Amaryl, Glimperide
Chemical Name: 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide
Biological Activity
Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.
Technical Data
  • M.Wt:
    490.62
  • Formula:
    C24H34N4O5S
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    93479-97-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sacrolemmal KATP channels.
    Lawrence et al.
    Br.J.Pharmacol., 2002;136:746

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