Glimepiride

Tocris Bioscience | Catalog # 2396

Kir6 (KATP) channel blocker
Tocris Bioscience
Discontinued Product
2396 has been discontinued. View all Inward Rectifier Potassium Channel Blockers products.

Key Product Details

Description

Kir6 (KATP) channel blocker

Alternative Names

Amaryl,Glimperide
View all Inward Rectifier Potassium Channel Blockers »

Product Description

Glimepiride is a potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

Product Specifications for Glimepiride

Molecular Weight

490.62

Formula

C24H34N4O5S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide

CAS Number

93479-97-1

PubChem ID

3476

InChI Key

WIGIZIANZCJQQY-UHFFFAOYSA-N

SMILES

O=C1C(CC)=C(C)CN1C(NCCC2=CC=C(S(NC(N[C@H]3CC[C@H](C)CC3)=O)(=O)=O)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.27 25

Preparing Stock Solutions for Glimepiride

The following data is based on the product molecular weight 490.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 8.15 mL 40.76 mL 81.53 mL
1.25 mM 1.63 mL 8.15 mL 16.31 mL
2.5 mM 0.82 mL 4.08 mL 8.15 mL
12.5 mM 0.16 mL 0.82 mL 1.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Glimepiride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Glimepiride

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Glimepiride (1)

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  • Glimepiride was used to evaluate the role of BK channel modulation on insulin secretion
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 11/28/2018
    In pancreatic beta cells,ATP dependent potassium channels regulate glucose-dependent insulin secretion and serve as the target for sulfonylurea drugs used to treat type 2 diabetes.To understand the role of BK channels on insulin secretion,Glimepiride was used.
    Glimepiride 2396

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