GSK 2250665A

Catalog # Availability Size / Price Qty
GSK 2250665A | CAS No. 1246030-96-5 | ITK Inhibitors
1 Image
Description: Itk inhibitor

Chemical Name: trans-4-[[4-[(6-Ethyl-2-benzothiazolyl)amino]-6-(phenylmethyl)-2-pyrimidinyl]amino]cyclohexanol

Purity: ≥97%

Product Details

Biological Activity

GSK 2250665A is an Itk inhibitor (pKi = 9.2). Exhibits selectivity for Itk over Aurora B kinase and Btk (pIC50 values are 6.4 and 6.5, respectively) and a panel of other kinases. Inhibits IFNγ production in PBMCs.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in 1eq. HCl
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. Identification of a novel and selective series of Itk inhibitors via a template-hopping strategy.
    Alder et al.
    ACS Med.Chem.Lett., 2013;12:948

Product Datasheets

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