GSK 2250665A

Key Product Details

Product Description

GSK 2250665A is an Itk inhibitor (pK_i = 9.2). Exhibits selectivity for Itk over Aurora B kinase and Btk (pIC₅₀ values are 6.4 and 6.5, respectively) and a panel of other kinases. Inhibits IFNγ production in PBMCs.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for GSK 2250665A

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for GSK 2250665A

The following data is based on the product molecular weight 459.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.18 mL	10.88 mL	21.76 mL
5 mM	0.44 mL	2.18 mL	4.35 mL
10 mM	0.22 mL	1.09 mL	2.18 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Alder Identification of a novel and selective series of Itk inhibitors via a template-hopping strategy. ACS Med.Chem.Lett. 2013 PMID: 24900590

Product Documents for GSK 2250665A