IBC 293
Chemical Name: 1-(1-Methylethyl)-1H-benzotriazole-5-carboxylic acid
Purity: ≥99%
Biological Activity
Highly selective agonist for GPR109B (HM74), human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over niacin receptor GPR109A (HM74A); EC50 values are 400 nM and > 1 μM respectively. Inhibits isoproterenol-stimulated lipolysis in vitro in isolated human adipocytes.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.
Semple et al.
J.Med.Chem., 2006;49:1227
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