IBC 293

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2469/10
2469/50
IBC 293 | CAS No. 306935-41-1 | Nicotinic Acid Receptor (GPR109) Agonists
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Description: Selective agonist for the GPR109B (HM74) receptor. Antilipolytic

Chemical Name: 1-(1-Methylethyl)-1H-benzotriazole-5-carboxylic acid

Purity: ≥99%

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Biological Activity

Highly selective agonist for GPR109B (HM74), human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over niacin receptor GPR109A (HM74A); EC50 values are 400 nM and > 1 μM respectively. Inhibits isoproterenol-stimulated lipolysis in vitro in isolated human adipocytes.

Technical Data

M.Wt:
205.22
Formula:
C10H11N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
306935-41-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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