Chemical Name: 1-(1-Methylethyl)-1H-benzotriazole-5-carboxylic acid
Biological Activity Highly selective agonist for GPR109B (HM74), human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over niacin receptor GPR109A (HM74A); EC50 values are 400 nM and > 1 μM respectively. Inhibits isoproterenol-stimulated lipolysis in vitro in isolated human adipocytes.
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at RT
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