Catalog Number: 3002
Chemical Name: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
Biological Activity
Antioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo. Inhibits apoptosis of astrocytes via increased NGF production.
Technical Data
  • M.Wt:
    338.44
  • Formula:
    C19H30O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    58186-27-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review.
    Zs-Nagy
    Arch.Gerontol.Geriatr., 1990;11:177
  2. Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes.
    Civenni et al.
    Eur.J.Pharmacol., 1999;370:161
  3. CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production.
    Takuma et al.
    Eur.J.Pharmacol., 2000;406:333

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