Antioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro
and in vivo
. Inhibits apoptosis of astrocytes via increased NGF production.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review.
Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes.
Civenni et al.
CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production.
Takuma et al.