Chemical Name: 11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime
Biological ActivitySelective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.
Schepetkin et al.
Citation for IQ 3
The citations listed below are publications that use Tocris products. Selected citations for IQ 3 include:
1 Citation: Showing 1 - 1
Genetic elimination of GABAergic neurotransmission reveals two distinct pacemakers for spontaneous waves of activity in the developing mouse cortex.
Authors: Easton Et al.
J Neurosci 2014;34:3854
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