Selective JNK3 inhibitor (Kd
values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-κ
B/AP1 transcriptional activity in THP1-Blue cells (IC50
= 1.4 μ
M). Also inhibits TNF-α
and IL-6 production in vitro
Soluble to 20 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.
Schepetkin et al.
The citations listed below are publications that use Tocris products. Selected citations for IQ 3 include:
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