Catalog Number: 4550
Chemical Name: 11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime
Biological Activity
Selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.
Technical Data
  • M.Wt:
    341.32
  • Formula:
    C20H11N3O3
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    312538-03-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.
    Schepetkin et al.
    Mol.Pharmacol., 2012;81:832
Citations:

The citations listed below are publications that use Tocris products. Selected citations for IQ 3 include:

1 Citations: Showing 1 - 1

  1. Genetic elimination of GABAergic neurotransmission reveals two distinct pacemakers for spontaneous waves of activity in the developing mouse cortex.
    Authors: Easton Et al.
    J Neurosci 2014;34:3854

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