Chemical Name: 11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime
Biological Activity Selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.
Soluble to 20 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
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