Catalog Number: 3262
Chemical Name: N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide
Biological Activity
Selective, reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 12 nM). Brain penetrant and active in vivo.
Technical Data
  • M.Wt:
    365.45
  • Formula:
    C19H19N5OS
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    681136-29-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amid hydrolase.
    Keith et al.
    Bioorg.Med.Chem.Lett., 2008;18:4838
Citations:

The citations listed below are publications that use Tocris products. Selected citations for JNJ 1661010 include:

2 Citations: Showing 1 - 2
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  1. The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119.
    Authors: Stone Et al.
    Br J Pharmacol 2012;165:2758
  2. Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines.
    Authors: Brown Et al.
    Carcinogenesis 2010;31:1584

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