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JNJ 78911118

Catalog #: 8970 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8970/10
8970/50

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JNJ 78911118 | NMDA Receptor Antagonists
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Description: Selective GluN2A antagonist, blood-brain barrier penetrant

Chemical Name: 5-(2-(4-Chloropyridin-2-yl)-2,2-difluoroethoxy)-6-methyl-N-(pyridin-3-ylmethyl)pyrazine-2-carboxamide

Purity: ≥98%

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Biological Activity

JNJ 78911118 is a potent, GluN2A-selective NMDA antagonist (IC50 = 44 nM). JNJ 78911118 shows >200-fold selectivity against GluN1/2B, 2C and 2D receptors. In vitro, JNJ 78911118 promotes increases in dendritic complexity and synapse number. In vivo, JNJ 78911118 increases mEPSC frequency in rat cortical neurons, and heart rate and blood pressure in rat toxicological studies. JNJ 78911118 is orally bioavailable and blood-brain barrier penetrant.

Technical Data

M.Wt:
419.82
Formula:
C19H16ClF2N5O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the JNJ 78911118 probe summary on the SGC website.

Product Datasheets

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