Catalog Number: 3143
Chemical Name: 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline
Biological Activity
Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structural analog of Sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect.
    Robert et al.
    Mol.Pharmacol., 2008;73:478

The citations listed below are publications that use Tocris products. Selected citations for KM 11060 include:

Showing Results 1 - 1 of 1

  1. Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice.
    Authors: Zhao Et al.
    J Neuroinflammation
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