Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
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Structural analog of Sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect.
Robert et al.
The citations listed below are publications that use Tocris products. Selected citations for KM 11060 include:
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