Catalog Number: 3143
Chemical Name: 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline
Biological Activity
Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
Technical Data
  • M.Wt:
    422.33
  • Formula:
    C19H17Cl2N3O2S
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    774549-97-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structural analog of Sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect.
    Robert et al.
    Mol.Pharmacol., 2008;73:478
Citations:

The citations listed below are publications that use Tocris products. Selected citations for KM 11060 include:

1 Citations: Showing 1 - 1

  1. Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice.
    Authors: Zhao Et al.
    J Neuroinflammation 2013;8:e82683

Have you used KM 11060?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information