Chemical Name: 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline
Biological ActivityCorrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Structural analog of silde. identified as a novel corrector of the F508del-CFTR trafficking defect.
Robert et al.
Citation for KM 11060
The citations listed below are publications that use Tocris products. Selected citations for KM 11060 include:
1 Citation: Showing 1 - 1
Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice.
Authors: Zhao Et al.
J Neuroinflammation 2013;8:e82683
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