L-364,373

Tocris Bioscience | Catalog # 2660

KV7.1 channel activator, activates IKs
Tocris Bioscience
Discontinued Product
2660 has been discontinued. View all Voltage-gated Potassium Channel Activators products.

Key Product Details

Description

KV7.1 channel activator, activates IKs

Alternative Names

R-L3
View all Voltage-gated Potassium Channel Activators »

Product Description

L-364,373 is an activator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.

Product Specifications for L-364,373

Molecular Weight

397.44

Formula

C25H20FN3O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one

CAS Number

103342-82-1

PubChem ID

656755

InChI Key

CGBANSGENFERAT-JOCHJYFZSA-N

SMILES

CN(C1=CC=CC=C1C(C5=CC=CC=C5F)=N[C@@H]2CC3=CNC4=C3C=CC=C4)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.74 100

Preparing Stock Solutions for L-364,373

The following data is based on the product molecular weight 397.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.50 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Product Documents for L-364,373

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L-364,373

For research use only

Customer Reviews for L-364,373 (1)

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  • L-364,373 activates IKs in ventricular cells isolated from rats
    Name: Eleanor Baxter
    Species: Rat
    Assay Type: In Vitro
    Verified Customer | Posted 10/23/2018
    L-364,373 activates IKs in ventricular cells isolated from rats. It shows potential as an antiarrhythmic drug.
    L-364,373 2660

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