Catalog Number: 2660
Alternate Names: R-L3
Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one
Biological Activity
Activator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.
Technical Data
  • M.Wt:
    397.44
  • Formula:
    C25H20FN3O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    103342-82-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels.
    Seebohm et al.
    Circ.Res., 2003;93:941
  2. Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373).
    Jow et al.
    Assay Drug Dev.Technol., 2006;4:443
  3. Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries.
    Chadha et al.
    Br.J.Pharmacol., 2012;166:1377
  4. A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents.
    Salata et al.
    Am.Soc.Pharmacol.Exp.Ther., 1998;53:220

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