L-364,373

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2660/10
2660/50
L-364,373 | CAS No. 103342-82-1 | Voltage-gated Potassium Channel Activators
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Description: KV7.1 channel activator, activates IKs
Alternative Names: R-L3

Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one

Purity: ≥98%

Product Details
Citations (4)
Reviews (1)

Biological Activity

Activator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.

Technical Data

M.Wt:
397.44
Formula:
C25H20FN3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
103342-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries.
    Chadha et al.
    Br.J.Pharmacol., 2012;166:1377
  2. Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels.
    Seebohm et al.
    Circ.Res., 2003;93:941
  3. Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373).
    Jow et al.
    Assay Drug Dev.Technol., 2006;4:443
  4. A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents.
    Salata et al.
    Am.Soc.Pharmacol.Exp.Ther., 1998;53:220

Product Datasheets

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Citations for L-364,373

The citations listed below are publications that use Tocris products. Selected citations for L-364,373 include:

4 Citations: Showing 1 - 4

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L-364,373 activates IKs in ventricular cells isolated from rats
By Eleanor Baxter on 10/23/2018
Species: Rat

L-364,373 activates IKs in ventricular cells isolated from rats. It shows potential as an antiarrhythmic drug.


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