L-364,373

  ( 3 citations )    
Product Datasheet
Catalog Number:2660
Alternate Names:R-L3
Chemical Name:5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one
Product Details
Citations (3)
Reviews
Biological Activity
Activator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.
Technical Data
  • M.Wt:
    397.44
  • Formula:
    C25H20FN3O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    103342-82-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-364,373 include:

3 Citations: Showing 1 - 3
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  1. Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K+ Channels.
    Authors: Noblet Et al.
    Arterioscler Thromb Vasc Biol  2015;35:1393
  2. Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity.
    Authors: Chadha Et al.
    Arterioscler Thromb Vasc Biol  2014;34:887
  3. Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries.
    Authors: Chadha Et al.
    Br J Pharmacol  2012;166:1377

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