Chemical Name: 5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one
Biological ActivityL-364,373 is an activator of KV7.1 (KCNQ1) channels. Activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries.
Chadha et al.
Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels.
Seebohm et al.
Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373).
Jow et al.
Assay Drug Dev.Technol., 2006;4:443
A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents.
Salata et al.
Citations for L-364,373
The citations listed below are publications that use Tocris products. Selected citations for L-364,373 include:
4 Citations: Showing 1 - 4
Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.
Authors: Amarelle Et al.
Am J Physiol Lung Cell Mol Physiol 2019;316:L1094
Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K+ Channels.
Authors: Noblet Et al.
Arterioscler Thromb Vasc Biol 2015;35:1393
Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity.
Authors: Chadha Et al.
Arterioscler Thromb Vasc Biol 2014;34:887
Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries.
Authors: Chadha Et al.
Br J Pharmacol 2012;166:1377
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L-364,373 activates IKs in ventricular cells isolated from rats. It shows potential as an antiarrhythmic drug.