Orally active Ca2+
channel blocker; inhibits K+
- and carbachol-stimulated Ca2+
values are 500 and 935 nM respectively). Exhibits antiproliferative, antiangiogenic and antimetastatic activity in vivo
and displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582
Hupe et al.
Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency.
Yang et al.
The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release.
Felder et al.