L-701,252

Key Product Details

Product Description

L-701,252 is a an antagonist at the glycine-NMDA site (IC₅₀ = 420 nM). Also a potent systemic anticonvulsant.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Product Specifications for L-701,252

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for L-701,252

The following data is based on the product molecular weight 263.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.58 mL	37.92 mL	75.85 mL
2.5 mM	1.52 mL	7.58 mL	15.17 mL
5 mM	0.76 mL	3.79 mL	7.58 mL
25 mM	0.15 mL	0.76 mL	1.52 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Stone Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 2000 PMID: 10740291
• Rowley 3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the NMDA receptor complex. J.Med.Chem. 1993 PMID: 8230129

Product Documents for L-701,252