Catalog Number: 0705
Chemical Name: 7-Chloro-3-(cyclopropylcarbonyl)-4-hydroxy-2(1H)-quinolinone
Biological Activity
An antagonist at the glycine-NMDA site (IC50 = 420 nM). Also a potent systemic anticonvulsant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Merck Sharp and Dohme Ltd.
Background References
  1. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection.
    TiPS, 2000;21:149
  2. 3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the NMDA receptor complex.
    Rowley et al.
    J.Med.Chem., 1993;36:3386
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