An antagonist at the glycine-NMDA site (IC50
= 420 nM). Also a potent systemic anticonvulsant.
Soluble to 50 mM in DMSO
Desiccate at +4°C
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All Tocris products are intended for laboratory research use only.
Sold with the permission of Merck Sharp and Dohme Ltd.
Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection.
3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the NMDA receptor complex.
Rowley et al.