L189

Catalog # Availability Size / Price Qty
3561/10
L189 | CAS No. 64232-83-3 | DNA Ligase Inhibitors
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Description: DNA ligase I, III and IV inhibitor

Chemical Name: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

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Biological Activity

DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

Technical Data

M.Wt:
246.29
Formula:
C11H10N4OS
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
64232-83-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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