DNA ligase I, III and IV inhibitor (IC50
values are 5, 9 and 5 μ
M respectively) that blocks DNA binding (Ki
= 5 μ
M for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair.
Chen X, Zhong S, Zhu X et al.