Chemical Name: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
Biological ActivityDNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair.
Chen X, Zhong S, Zhu X et al.
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