LOE 908 hydrochloride

Key Product Details

Product Description

LOE 908 hydrochloride is a broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na⁺ and K⁺ channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.

Product Specifications for LOE 908 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LOE 908 hydrochloride

The following data is based on the product molecular weight 749.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.33 mL	6.67 mL	13.35 mL
5 mM	0.27 mL	1.33 mL	2.67 mL
10 mM	0.13 mL	0.67 mL	1.33 mL
50 mM	0.03 mL	0.13 mL	0.27 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Krause LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture. Biochem.Biophys.Res.Comm. 1998 PMID: 9535721
• Tatlisumak Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat. J.Neurol.Sci. 2000 PMID: 11018702
• Christensen The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin.Pharmacol.Toxicol. 2005 PMID: 15755315

Product Documents for LOE 908 hydrochloride