LOE 908 hydrochloride
Chemical Name: 3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamide hydrochloride
Biological ActivityBroad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na+ and K+ channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study.
Christensen et al.
Basic Clin.Pharmacol.Toxicol., 2005;96:316
LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture.
Krause et al.
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat.
Tatlisumak et al.
Citations for LOE 908 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for LOE 908 hydrochloride include:
2 Citations: Showing 1 - 2
Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.
Authors: Varadarajan Et al.
PLoS One 2013;8:e56603
Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets.
Authors: Harper and Poole
J Biol Chem 2010;285:19865
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