Catalog Number: 2314
Chemical Name: 3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamide hydrochloride
Biological Activity
Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na+ and K+ channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.
Technical Data
  • M.Wt:
    749.29
  • Formula:
    C41H48N2O9.HCl
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    143482-60-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study.
    Christensen et al.
    Basic Clin.Pharmacol.Toxicol., 2005;96:316
  2. LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture.
    Krause et al.
    Biochem.Biophys.Res.Comm., 1998;244:659
  3. Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat.
    Tatlisumak et al.
    J.Neurol.Sci., 2000;178:107
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LOE 908 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.
    Authors: Varadarajan Et al.
    PLoS One 2013;8:e56603
  2. Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets.
    Authors: Harper and Poole
    J Biol Chem 2010;285:19865

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