Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na+
channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.
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The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study.
Christensen et al.
Basic Clin.Pharmacol.Toxicol., 2005;96:316
LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture.
Krause et al.
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat.
Tatlisumak et al.
The citations listed below are publications that use Tocris products. Selected citations for LOE 908 hydrochloride include:
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