Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na
channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.
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All Tocris products are intended for laboratory research use only.
The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study.
Christensen et al.
Basic Clin.Pharmacol.Toxicol., 2005;96:316
LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture.
Krause et al.
Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat.
Tatlisumak et al.
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