MB 05032

Catalog # Availability Size / Price Qty
6618/10
6618/50
Cat.No. 6618 - MB 05032 | C11H15N2O4PS | CAS No. 261365-11-1
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Description: Potent FBPase inhibitor; promotes HSC expansion

Chemical Name: P-[5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid

Purity: ≥98%

Product Details
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Biological Activity

Potent FBPase inhibitor (EC50 values are 1.6, 29 and 61 nM for human liver FBPase, human muscle FBPase and rat liver FBPase). Promotes hematopoietic stem cell and progenitor cell expansion. Increases engraftment in primary NSG mice recipients. Also enhances myeloid and lymphoid chimerism in secondary NSG mouse recipients. Promotes glycolysis, glucose uptake and lactate production in umbilical cord blood CD34+ cells.

Technical Data

M.Wt:
302.29
Formula:
C11H15N2O4PS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
261365-11-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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