ME 0328

Key Product Details

Product Description

ME 0328 is an inhibitor of PARP-3 (IC₅₀ = 0.89 μM). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC₅₀ values are 6.3, 10.8 and >30 μM respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable.

Product Specifications for ME 0328

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ME 0328

The following data is based on the product molecular weight 321.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.11 mL	15.56 mL	31.12 mL
5 mM	0.62 mL	3.11 mL	6.22 mL
10 mM	0.31 mL	1.56 mL	3.11 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wang and Sun CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Lett. 2016 PMID: 27815036
• Lindgren PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem.Biol. 2013 PMID: 23742272

Product Documents for ME 0328