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ME 0328

5054 2 Citations Datasheet / COA / SDS
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5054/10
5054/50
ME 0328 | CAS No. 1445251-22-8 | Poly(ADP-ribose) Polymerase Inhibitors
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Description: Selective PARP-3 inhibitor

Chemical Name: 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Inhibitor of PARP-3 (IC50 = 0.89 μM). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable.

Technical Data

M.Wt:
321.37
Formula:
C19H19N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1445251-22-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for ME 0328

The citations listed below are publications that use Tocris products. Selected citations for ME 0328 include:

2 Citations: Showing 1 - 2

  1. CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation.
    Authors: Wang and Sun
    Cancer Letters  2016;385:137
  2. CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation.
    Authors: Wang and Sun
    Cancer Lett.  2016;

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