ME 0328

  ( 2 citations )    
Product Datasheet
Catalog Number:5054
Chemical Name:3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
Product Details
Citations (2)
Reviews
Biological Activity
Inhibitor of PARP-3 (IC50 = 0.89 μM). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable.
Technical Data
  • M.Wt:
    321.37
  • Formula:
    C19H19N3O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    1445251-22-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ME 0328 include:

2 Citations: Showing 1 - 2
Filter your results:

  1. CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation.
    Authors: Wang and Sun
    Cancer Letters  2016;385:137
  2. CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation.
    Authors: Wang and Sun
    Cancer Lett.  2016;

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used ME 0328?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee