ME 0328
Chemical Name: 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
Purity: ≥98%
Biological Activity
Inhibitor of PARP-3 (IC50 = 0.89 μM). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
Lindgren et al.
ACS Chem.Biol., 2013;8:1698 -
CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation.
Wang and Sun
Cancer Lett., 2016;
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for ME 0328
The citations listed below are publications that use Tocris products. Selected citations for ME 0328 include:
2 Citations: Showing 1 - 2
-
CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation.
Authors: Wang and Sun
Cancer Letters 2016;385:137
-
CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation.
Authors: Wang and Sun
Cancer Lett. 2016;
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for ME 0328
There are currently no reviews for this product. Be the first to review ME 0328 and earn rewards!
Have you used ME 0328?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image