Catalog Number: 5054
Chemical Name: 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
Biological Activity
Inhibitor of PARP-3 (IC50 = 0.89 μM). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable.
Technical Data
  • M.Wt:
    321.37
  • Formula:
    C19H19N3O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1445251-22-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
    Lindgren et al.
    ACS Chem.Biol., 2013;8:1698
  2. CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation.
    Wang and Sun
    Cancer Lett., 2016;
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ME 0328 include:

2 Citations: Showing 1 - 2
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  1. CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation.
    Authors: Wang and Sun Et al.
    Cancer Letters 2016;385:137
  2. CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation.
    Authors: Wang and Sun
    Cancer Lett. 2016;

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