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Mephenytoin

3276 Datasheet / COA / SDS
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3276/10
Mephenytoin | CAS No. 50-12-4 | Cytochrome P450 Substrates
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Description: CYP2C19 substrate. Anticonvulsant

Chemical Name: (±)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione

Purity: ≥98%

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Biological Activity

Mephenytoin is a CYP2C19 and CYP2B6 substrate. Anticonvulsant.

Technical Data

M.Wt:
218.25
Formula:
C12H14N2O2
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
50-12-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. CYP2C19 inhibition: the impact of substrate probe selection on in vitro inhibition profiles.
    Foti et al.
    Drug Meta. Dispos., 2008;36:523
  2. Mephenytoin as a probe for CYP2C19 phenotyping: effect of sample storage, intra-individual reproducibility and occurrence of adverse events.
    Tamminga et al.
    Br.J.Clin.Pharmacol., 2001;51:471
  3. Racemic and optically active hydantoins from disubstituted cyanoacetic acids.
    Knabe and Wunn
    Arch.Pharmacol., 1980;313:53

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