Milameline hydrochloride

Key Product Details

Product Description

Milameline hydrochloride is a muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (K_i values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for hM₁, hM₂, hM₃, hM₄ and hM₅ receptors respectively). Cognitive enhancer; reverses spatial memory deficits in rats.

Product Specifications for Milameline hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Milameline hydrochloride

The following data is based on the product molecular weight 190.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.24 mL	26.22 mL	52.45 mL
5 mM	1.05 mL	5.24 mL	10.49 mL
10 mM	0.52 mL	2.62 mL	5.24 mL
50 mM	0.10 mL	0.52 mL	1.05 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wood Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM₁, hM₂, hM₃, hM₄ and hM₅ using microphysiometry. Br.J.Pharmacol. 1999 PMID: 10323594
• Schwarz Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization. J.Pharmacol.Exp.Ther. 1999 PMID: 10525104
• Sedman Preclinical and phase I clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease. Life Sci. 1995 PMID: 10188788

Product Documents for Milameline hydrochloride