Mitoglitazone

Key Product Details

Product Description

Mitoglitazone is an insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ (EC₅₀ = 23.7 μM).

Product Specifications for Mitoglitazone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Mitoglitazone

The following data is based on the product molecular weight 370.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.70 mL	13.50 mL	27.00 mL
5 mM	0.54 mL	2.70 mL	5.40 mL
10 mM	0.27 mL	1.35 mL	2.70 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chen Ins resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J.Biol.Chem. 2012 PMID: 22621923
• Colca Identification of a mitochondrial target of thiazolidinedione Ins sensitizers (mTOT) relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One 2013 PMID: 23690925
• Divakaruni Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc.Natl.Acad.Sci.U.S.A. 2013 PMID: 23513224

Product Documents for Mitoglitazone