Catalog Number: 5799
Alternate Names: CAY 10415, MSDC 0160
Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione
Biological Activity
Insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ (EC50 = 23.7 μM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT) relationship to newly identified mitochondrial pyruvate carrier proteins.
    Colca et al.
    PLoS One, 2013;8:e61551
  2. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.
    Divakaruni et al.
    Proc.Natl.Acad.Sci.U.S.A., 2013;110:5422
  3. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione.
    Chen et al.
    J.Biol.Chem., 2012;287:23537
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