Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione
Biological Activity Insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ (EC50 = 23.7 μM).
Soluble to 100 mM in DMSO
Store at -20°C
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