Mitoglitazone

Catalog # Availability Size / Price Qty
5799/10
5799/50
Cat.No. 5799 - Mitoglitazone | C19H18N2O4S | CAS No. 146062-49-9
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Description: Insulin sensitizer; exhibits low binding affinity at PPARγ
Alternative Names: CAY 10415, MSDC 0160

Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione

Purity: ≥98%

Product Details
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Biological Activity

Insulin sensitizer; enhances insulin sensitivity and lowers blood-glucose levels in diabetic mouse models. Inhibits mitochondria pyruvate carriers; increases mitochondrial respiration rates, leading to a reduction in expression of lipogenic enzymes. Suppresses gluconeogenesis and lipogenesis in primary hepatocytes. Exhibits low binding affinity and activity at PPARγ (EC50 = 23.7 μM).

Technical Data

M.Wt:
370.42
Formula:
C19H18N2O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
146062-49-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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