ML 10302 hydrochloride

Catalog # Availability Size / Price Qty
3499/10
3499/50
ML 10302 hydrochloride | CAS No. 186826-17-5 | 5-HT4 Receptor Agonists
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Description: Potent and selective 5-HT4 partial agonist

Chemical Name: 4-Amino-5-chloro-2-methoxybenzoic acid 2-(1-piperidinyl)ethyl ester hydrochloride

Purity: ≥99%

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Biological Activity

Potent 5-HT4 partial agonist (EC50 = 4 nM) that displays > 680-fold selectivity over 5-HT3 receptors (Ki values are 1.07 and 730 nM respectively). Increases sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibits progastrokinetic effects in vivo.

Technical Data

M.Wt:
349.25
Formula:
C15H21ClN2O3.HCl
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
186826-17-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.
    Yang et al.
    J.Med.Chem., 1997;40:608
  2. 5-HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice.
    Cachard-Chastel et al.
    Br.J.Pharmacol., 2007;150:883
  3. Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon.
    Ponti et al.
    Neurogastroenterol.Mot., 2001;13:543

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