ML 10302 hydrochloride

Key Product Details

Product Description

ML 10302 hydrochloride is a potent 5-HT₄ partial agonist (EC₅₀ = 4 nM) that displays > 680-fold selectivity over 5-HT₃ receptors (K_i values are 1.07 and 730 nM respectively). Increases sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibits progastrokinetic effects in vivo.

Product Specifications for ML 10302 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 10302 hydrochloride

The following data is based on the product molecular weight 349.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.73 mL	28.63 mL	57.27 mL
2.5 mM	1.15 mL	5.73 mL	11.45 mL
5 mM	0.57 mL	2.86 mL	5.73 mL
25 mM	0.11 mL	0.57 mL	1.15 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Cachard-Chastel 5-HT₄ receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice. Br.J.Pharmacol. 2007 PMID: 17325649
• Ponti Intestinal motor stimulation by the 5-HT₄ receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol.Mot.
• Yang New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT₄ receptors. J.Med.Chem. 1997 PMID: 9046352

Product Documents for ML 10302 hydrochloride