Inhibitor of protease-activated receptor 1 (PAR1
)-mediated platelet activation (IC50
= 0.26 μ
M for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.
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All Tocris products are intended for laboratory research use only.
Discovery of 1,3-diaminobenzenes as selective inhibitors of platelet activation at the PAR1 receptor.
Dockendorff et al.
ACS Med.Chem.Lett., 2012;3:232