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ML 161

Catalog #: 4570 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4570/10
4570/50
ML 161 | CAS No. 423735-93-7 | Protease-Activated Receptor Inhibitors
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Description: Inhibits PAR1-mediated platelet activation

Chemical Name: 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide

Purity: ≥98%

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Biological Activity

ML 161 is an inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.

Technical Data

M.Wt:
361.23
Formula:
C17H17BrN2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
423735-93-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of 1,3-diaminobenzenes as selective inhibitors of platelet activation at the PAR1 receptor.
    Dockendorff et al.
    ACS Med.Chem.Lett., 2012;3:232

Product Datasheets

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FAQs

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VersaClone cDNA Plasmids

Human PAR1 (NP_001983) VersaClone cDNA

RDC0164

Mouse PAR1 (NP_034299) VersaClone cDNA

RDC0165

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