Chemical Name: 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide
Biological ActivityML 161 is an inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of 1,3-diaminobenzenes as selective inhibitors of platelet activation at the PAR1 receptor.
Dockendorff et al.
ACS Med.Chem.Lett., 2012;3:232
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