ML 289

Key Product Details

Product Description

ML 289 is a selective negative allosteric modulator at mGlu₃ receptors (IC₅₀ = 660 nM). Exhibits 15-fold selectivity for mGlu₃ over mGlu₂. Centrally penetrant.

Product Specifications for ML 289

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 289

The following data is based on the product molecular weight 349.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.86 mL	14.31 mL	28.62 mL
5 mM	0.57 mL	2.86 mL	5.72 mL
10 mM	0.29 mL	1.43 mL	2.86 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sheffler Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg.Med.Chem.Lett. 2012 PMID: 22607673

Product Documents for ML 289