ML 289
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Description: Selective negative allosteric modulator of mGlu3
Chemical Name: [(3R)-3-(Hydroxymethyl)-1-pipridinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanone
Purity: ≥98%
Biological Activity
Selective negative allosteric modulator at mGlu3 receptors (IC50 = 660 nM). Exhibits 15-fold selectivity for mGlu3 over mGlu2. Centrally penetrant.Technical Data
M.Wt:
349.42
Formula:
C22H23NO3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1382481-79-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
-
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.
Sheffler et al.
Bioorg.Med.Chem.Lett., 2012;22:3921
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