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ML 289

4976 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4976/10
4976/50
Group II mGluR Modulators Small Molecule
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Description: Selective negative allosteric modulator of mGlu3 receptors

Chemical Name: [(3R)-3-(Hydroxymethyl)-1-pipridinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanone

Purity: ≥98%

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Biological Activity

Selective negative allosteric modulator at mGlu3 receptors (IC50 = 660 nM). Exhibits 15-fold selectivity for mGlu3 over mGlu2. Centrally penetrant.

Technical Data

M.Wt:
349.42
Formula:
C22H23NO3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1382481-79-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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VersaClone cDNA Plasmids

Human mGluR3 (NP_000831) VersaClone cDNA

RDC1012

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