Catalog Number: 3747
Alternate Names: PTACH
Chemical Name: 2-Methylpropanethioic acid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester
Biological Activity
Histone deacetylase (HDAC) inhibitor. Inhibits growth of various cancer cells in vitro (EC50 = 1.1 - 9.1 μM).
Technical Data
  • M.Wt:
    390.56
  • Formula:
    C20H26N2O2S2
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    848354-66-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates.
    Suzuki et al.
    J.Med.Chem., 2005;48:1019
  2. Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells.
    Sanda et al.
    Leukemia, 2007;21:2344

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