NCS-382

Name: NCS-382
Brand: Tocris Bioscience
SKU: 0780

Tocris Bioscience | Catalog # 0780

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Product Documents

Antagonist of γ-hydroxybutyric acid

Discontinued Product

0780 has been discontinued. View all Additional GABA Compounds products.

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Antagonist of γ-hydroxybutyric acid

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Product Description

NCS-382 is a γ-Hydroxybutyric acid antagonist, anticonvulsant.

Product Specifications for NCS-382

Molecular Weight

218.25

Formula

C₁₃H₁₄O₃

Storage

Desiccate at +4°C

Purity

≥99% (HPLC)

Chemical Name

6,7,8,9-Tetrahydro-5-hydroxy-5H-benzocyclohept-6-ylideneacetic acid

CAS Number

520505-01-5

PubChem ID

5875451

InChI Key

UADPGHINQMWEAG-CSKARUKUSA-N

SMILES

OC1C2=C(CCC\C1=C/C(O)=O)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.83	100

Preparing Stock Solutions for NCS-382

The following data is based on the product molecular weight 218.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.58 mL	22.91 mL	45.82 mL
5 mM	0.92 mL	4.58 mL	9.16 mL
10 mM	0.46 mL	2.29 mL	4.58 mL
50 mM	0.09 mL	0.46 mL	0.92 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product.

Maitre A specific γ-hydroxybutyrate receptor ligand possesses both antagonist and anticonvulsant properties. J.Pharmacol.Exp.Ther. 1990 PMID: 2173754
Schmidt Anti-sedative and anti-cataleptic properties of NCS-382, a γ-hydroxybutyrate receptor antagonist. Eur.J.Pharmacol. 1991 PMID: 1773824
King Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice. J.Neural Transm. 1997 PMID: 9503264

Product Documents for NCS-382

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for NCS-382

For research use only

Related Research Areas

Osteoblast and Osteoclast Markers

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