NFAT Inhibitor

Catalog # Availability Size / Price Qty
3930/1
NFAT Inhibitors Peptide
1 Image
Description: Inhibitor of calcineurin-mediated NFAT activation
Alternative Names: VIVIT peptide
Product Details
Citations (1)
Reviews

Biological Activity

Selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

Technical Data

M.Wt:
1683.94
Formula:
C75H118N20O22S
Sequence:
MAGPHPVIVITGPHEE
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
249537-73-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.
    Aramburu et al.
    Science, 1999;285:2129
  2. Microglial phenotype is regulated by activity of the transcription factor, NFAT (Nuclear Factor of Activated T Cells).
    Nagamoto-Combs and Combs
    J.Neurosci., 2010;30:9641
  3. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.
    Roehrl et al.
    Proc.Natl.Acad.Sci.USA, 2004;101:7554

Product Datasheets

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Citation for NFAT Inhibitor

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