Biological ActivitySelective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.
Aramburu et al.
Microglial phenotype is regulated by activity of the transcription factor, NFAT (Nuclear Factor of Activated T Cells).
Nagamoto-Combs and Combs
Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.
Roehrl et al.
Citation for NFAT Inhibitor
The citations listed below are publications that use Tocris products. Selected citations for NFAT Inhibitor include:
1 Citation: Showing 1 - 1
Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses.
Authors: Noren Et al.
Sci Signal 2016;9:ra20
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