Catalog Number: 3930
Alternate Names: VIVIT peptide
Biological Activity
Selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.
Technical Data
  • M.Wt:
    1683.94
  • Formula:
    C75H118N20O22S
  • Sequence:
    MAGPHPVIVITGPHEE
  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    249537-73-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.
    Aramburu et al.
    Science, 1999;285:2129
  2. Microglial phenotype is regulated by activity of the transcription factor, NFAT (Nuclear Factor of Activated T Cells).
    Nagamoto-Combs and Combs
    J.Neurosci., 2010;30:9641
  3. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.
    Roehrl et al.
    Proc.Natl.Acad.Sci.USA, 2004;101:7554

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