Catalog Number: 3546
Chemical Name: (S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt
Biological Activity
Nicotinic acetylcholine receptor (nAChR) agonist (Ki values are 1, > 1000, 4000 and 7130 nM at α4β2, α1β1δγ, rat α7 and human α7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo.
Technical Data
  • M.Wt:
    462.41
  • Formula:
    C10H14N2.2C4H6O6
  • Solubility:
    Soluble to 100 mM in water and to 75 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    65-31-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I In vitro characterization.
    Donnelly-Roberts et al.
    J.Pharmacol.Exp.Ther., 1998;285:777
  2. Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function.
    Xiao et al.
    Mol.Pharmacol., 1998;54:322
  3. Acute infusion of nicotine potentiates norepinephrine-induced vasoconstriction in the hamster cheek pouch.
    Mayhan
    J.Lab.Clin.Med., 1999;133:48
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (-)-Nicotine ditartrate include:

5 Citations: Showing 1 - 5
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  1. Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
    Authors: Miguel Angel Garcia-Bereguiain Et al.
    The Journal of Neuroscience 2016;6:7268
  2. Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B.
    Authors: Tang Et al.
    Iran Biomed J 2015;36:800
  3. Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats.
    Authors: Chalabi-Yani Et al.
    Elife 2015;19:214
  4. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.
    Authors: Owaisat Et al.
    Neurosci Lett 2012;525:12
  5. OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons.
    Authors: Leão Et al.
    Nat Neurosci 2012;15:1524

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