Home / Additional Nicotinic Receptor Agonists / (-)-Nicotine ditartrate

(-)-Nicotine ditartrate

Catalog #: 3546
12 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3546/50
(-)-Nicotine ditartrate | CAS No. 65-31-6 | Additional Nicotinic Receptor Agonists
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Description: Prototypical nAChR agonist

Chemical Name: (S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt

Purity: ≥99%

Product Details
Citations (12)
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Biological Activity

(-)-Nicotine ditartrate is a nicotinic acetylcholine receptor (nAChR) agonist (Ki values are 1, > 1000, 4000 and 7130 nM at α4β2, α1β1δγ, rat α7 and human α7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo.

Technical Data

M.Wt:
462.41
Formula:
C10H14N2.2C4H6O6
Solubility:
Soluble to 100 mM in water and to 75 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
65-31-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Nicotine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for (-)-Nicotine ditartrate

The citations listed below are publications that use Tocris products. Selected citations for (-)-Nicotine ditartrate include:

12 Citations: Showing 1 - 10

  1. β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue.
    Authors: Jean-Marie Et al.
    Front Behav Neurosci  2022;16:1004368
  2. Chronic Lorcaserin Treatment Reverses the Nicotine Withdrawal-Induced Disruptions to Behavior and Maturation in Developing Neurons in the Hippocampus of Rats.
    Authors: Marzena Et al.
    Int J Mol Sci  2021;22
  3. A molecular filter for the cnidarian stinging response.
    Authors: Lena Et al.
    Elife  2020;9
  4. NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly.
    Authors: David S Et al.
    Cell Rep  2020;32:108025
  5. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
    Authors: Dorst Et al.
    Nat Commun  2020;11:5113
  6. α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components.
    Authors: Gu Et al.
    Cell Rep  2019;26:866
  7. Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models.
    Authors: Asami Et al.
    Neuron  2019;101:444-458.e6
  8. Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
    Authors: Miguel Angel Garcia-Bereguiain Et al.
    The Journal of Neuroscience  2016;6:7268
  9. Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B.
    Authors: Tang Et al.
    Iran Biomed J  2015;36:800
  10. Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats.
    Authors: Chalabi-Yani Et al.
    Elife  2015;19:214

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VersaClone cDNA Plasmids

Human nAChR alpha 2/CHRNA2 (AAB40109) VersaClone cDNA

RDC0699

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