Nicotinic acetylcholine receptor (nAChR) agonist (Ki
values are 1, > 1000, 4000 and 7130 nM at α
, rat α
7 and human α
7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo
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ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I In vitro characterization.
Donnelly-Roberts et al.
Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function.
Xiao et al.
Acute infusion of nicotine potentiates norepinephrine-induced vasoconstriction in the hamster cheek pouch.
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