Chemical Name: (S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt
Biological Activity(-)-Nicotine ditartrate is a nicotinic acetylcholine receptor (nAChR) agonist (Ki values are 1, > 1000, 4000 and 7130 nM at α4β2, α1β1δγ, rat α7 and human α7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo.
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ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I In vitro characterization.
Donnelly-Roberts et al.
Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function.
Xiao et al.
Acute infusion of nicotine potentiates NE-induced vasoconstriction in the hamster cheek pouch.
Citations for (-)-Nicotine ditartrate
The citations listed below are publications that use Tocris products. Selected citations for (-)-Nicotine ditartrate include:
7 Citations: Showing 1 - 7
Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
Authors: Dorst Et al.
Nat Commun 2020;11:5113
α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components.
Authors: Gu Et al.
Cell Rep 2019;26:866
Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
Authors: Miguel Angel Garcia-Bereguiain Et al.
The Journal of Neuroscience 2016;6:7268
Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B.
Authors: Tang Et al.
Iran Biomed J 2015;36:800
Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats.
Authors: Chalabi-Yani Et al.
In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.
Authors: Owaisat Et al.
Neurosci Lett 2012;525:12
OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons.
Authors: Leão Et al.
Nat Neurosci 2012;15:1524
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